Health Care

Penny-sized nanochip pad can regrow organs and heal injuries

Penny-sized nanochip pad can regrow organs and heal injuries”

So the news that researchers at The Ohio State University Wexner Medical Centre and Ohio State's College of Engineering have developed a revolutionary new organ-healing microtechnology comes as a welcome change.

The technology itself comprises two relatively simple components: a nanotechnology-based chip created to deliver "biological cargo" to adult cells in the (live) body; and the design of aforementioned "biological cargo" to kickstart the cell conversion. The procedure is non-invasive in nature and takes less than a second.

In less than a second, this chip would deliver reprogramming factors (pre-programmed DNA or RNA) non-invasively into living skin cells via a high-intensity, focused electric field, converting them into whatever type of cells a scientist or doctor may choose.

It instantly delivers new DNA or RNA into living skin cells to change their function, with a small electrical charge that's barely felt by the patient, thus aiding the speedy fix of injured tissue as well as restoring the function of ageing tissue, including organs.

Researchers from Ohio State University call the new technology tissue nanotransfection (TNT). Researchers grew brain cells on the skin surface of a mouse, harvested them and then injected them into the brain.

Dr. Chandan Sen, director of Ohio State's Centre for Regenerative Medicine and Cell Based Therapies said of the development: "This is hard to imagine, but it is achievable, successfully working about 98% of the time".

"This is hard to imagine, but it is achievable, successfully working about 98 per cent of the time", Sen said, adding the researchers plan to start clinical trials next year in humans.

Says Sen: "By using our novel nanochip technology, injured or compromised organs can be replaced". Mice with badly injured legs that lacked blood flow were healed within three weeks and blood flow was restored. The cargo is delivered by a small electrical charge zapping the device.

"The concept is very simple", Lee said. "So this is the beginning, more to come".

Chandan Sen, the director of the Center for Regenerative Medicine and Cell-Based Therapies and co-leader of the study, said he expects the technology will be tested on humans within the next year and that he's now in talks with Walter Reed National Medical Center about human trials, USA Today reported.

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