Health Care

Sugars in Mother's Milk Exhibit Antibacterial Properties

Sugars in Mother's Milk Exhibit Antibacterial Properties”

In the past, scientists have concentrated their search for the source of its antibacterial properties on the proteins it contains. He also explained that one of the best things about these antibiotics in human milk is that they are non-toxic - something that traditional antibiotics are not.

In their quest for insights, Townsend and team were motivated by the growing problem of antibiotic resistance in bacteria, which the US government estimates is responsible for about 23,000 deaths each year.

Researchers, instead of searching for proteins in human milk with antimicrobial properties, looked at the sugars.

"When bacteria want to harm us, they produce this gooey protective substance", Townsend explains, "which allows them to thwart our defence mechanisms".

"In most women, the group B strep that is present will not cause illness".

"Our results show that these sugars have a one-two punch". Dr. Townsend explained why, in a press release, "For most of the last century, biochemists have argued that proteins are most important and sugars are an afterthought".

It is often recommended that mother's milk should be the first food given to a new-born as it contains all the essential minerals and nutrients that they require for their growth and development.

In addition, the team says its preliminary, still-in-progress data indicates that milk sugars can make bacteria more susceptible to common antibiotics - such as penicillin and erythromycin. "Far less is known about the function of sugars and, as a trained glycoprotein chemist, I wanted to explore their role".

The team collected human milk carbohydrates, also known as oligosaccharides, and profiled them using mass spectrometry.

In the current study, his team members are testing more than a dozen additional milk samples to see if they can replicate their first round of results. Under a microscope they found the sugars not only killed bacteria, but disintegrated the biofilm strep uses to protect itself.

In a pilot study, Townsend's lab collected five samples.

"As carbohydrate chemists, we knew from previous research that milk carbohydrates are protective against other bacteria, so we figured there would be a chance they would be active against group B strep, too", says Townsend, who is at Vanderbilt University.

Almost 10 years ago, researchers had found that pregnant women play host to group B strep bacteria and the pathogen can be transmitted to infants through breastfeeding. In another, they were moderately effective at killing the strep, while in the remaining three samples the carbohydrates weren't very effective.

Said Townsend: "Our results show that these sugars have a one-two punch...."

So far, two broke down the bacterial biofilms and killed the bacteria, four broke down the biofilms but did not kill the bacteria and two killed the bacteria without breaking down the biofilms, researchers said. "Biologist sometimes call this "synthetic lethality" and there is a major push to develop new antimicrobial drugs with this capability". Breast milk sugars could successfully handle tow of these pathogens as well as numerous other bacterial infections found some of the follow up studies.

The researchers are also working identify the specific types of carbohydrate molecules responsible for the antibacterial effects they have discovered. The Department of Veterans Affairs, the National Institutes of Health, the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Vanderbilt Institute of Chemical Biology supported the research.



Like this

loading...
loading...

Latest


24 August 2017
The Eastman Chemical Company (EMN) Given "Outperform" Rating at Cowen and Company
Eastman Chemical Company (NYSE:EMN) Chemicals - Major Diversified shows a Dividend Yield of 2.45% with a Payout Ratio of 30.90%. Northwestern Mutual Wealth Management Company increased Eastman Chem Co ( EMN ) stake by 444.34% reported in 2016Q4 SEC filing.

24 August 2017
MTV Greenlights Season Two of Fear Factor Revival
The latest version sees contestants tackle stunts inspired by urban legends and taken from popular movies and viral videos. The network renewed the Ludacris-hosted competition for Season 2 on Tuesday, Variety reports.

24 August 2017
Motter lifts Mariners past Braves 9
Seattle's Erasmo Ramirez gave up three runs and six hits and struck out six, matching his season high, in six innings. Freddie Freeman drove in two runs with two hits, including a run-scoring single off Nick Vincent in the eighth.

24 August 2017
Hot Stocks For Today: Fifth Third Bancorp (FITB), Paychex, Inc. (PAYX)
The sale was disclosed in a legal filing with the Securities & Exchange Commission, which is accessible through the SEC website . Analyst Recommendations are opinions given by analysts to their clients about whether a given stock is worth buying or not.

24 August 2017
Hudbay Minerals Inc (HBM) Earns Buy Rating from Eight Capital
Moreover, Doliver Capital Advsr Inc has 0.15% invested in Duff & Phelps Utility & Corp Bond Trust (NYSE:DUC) for 18,781 shares. Zacks Investment Research raised Hudbay Minerals from a "sell" rating to a "hold" rating in a report on Thursday, August 10th.

24 August 2017
Clear Harbor Asset Management LLC Raises Stake in FedEx Corporation (FDX)
Cohen Capital Management Inc. acquired a new position in FedEx Corporation during the first quarter worth about $185,000. FedEx Corporation (NYSE:FDX) last issued its earnings results on Tuesday, June 20th. 10 accumulated 14,192 shares.

24 August 2017
Analyzing Analyst Recommendations: CONSOL Energy Inc. (CNX), The Macerich Company (MAC)
Also Nasdaq.com published the news titled: "CONSOL Energy (CNX) Exceeds Q2 Earnings & Revenue Estimates" on August 01, 2017. Clarkson Capital restated a "buy" rating on shares of CNX Coal Resources in a research note on Wednesday, July 12th.

24 August 2017
Exclusive Pictures and Videos: Priyamani, Mustufa Raj enter wedlock in registrar office
The wedding reception will be held this evening in Bengaluru, where the who's who of the South film industry is slated to attend. Priyamani was last seen in Tamil film Chowka. "We opted for registered marriage because we are from different religions".

24 August 2017
Rumor - Skyrim for Nintendo Switch Release Date Listed on Amazon UK
What's more, is that initial reports of the game have been very positive, citing smooth framerates and impressive visuals. It's the consistency in performance that's really impressive, especially compared to the last-gen versions of the game.

24 August 2017
Jai Lava Kusa Audio Event on Sep 3rd
Rashi Khanna and Nivetha Thomas are the female leads in the movie which has been aimed for Dasara release. The audio launch ceremony will be held in grand manner on 3rd September in Hyderabad.