Health Care

Dr. Weber on CheckMate-238 for Melanoma

Dr. Weber on CheckMate-238 for Melanoma”

The trial included 906 patients with stages IIIB, IIIC, and IV resected melanoma who had a greater than 50% risk of relapse over five years.

"Our results demonstrate that nivolumab is more effective in treating patients with stage III and IV melanoma, cutting the risk of relapse by a third", said Principal investigator Dr Jeffrey S. Weber, Professor of medicine at NYU School of Medicine and deputy director of Perlmutter Cancer Center. "This shows the magnitude of benefit is impressive, and that this is the real deal". Ipilimumab is also the Food and Drug Administration (FDA)-approved standard of care adjuvant therapy for resected stage III melanoma in the US.

Another anti-PD-1 drug, pembrolizumab, is being tested as adjuvant therapy against placebo in patients with resected stage III melanoma in a phase III European Organisation for Research and Treatment of Cancer (EORTC) trial.

The majority (81%) of patients had stage III disease, 32% had ulcerated primary melanoma, 48% had macroscopic lymph node involvement and 42% harbored BRAF mutations.

After 12 months of continuous therapy, 71% of patients treated with nivolumab lived without recurrence of the disease, compared with 61% of those treated with ipilimumab. RFS in the intent-to-treat population served as the primary endpoint.

Median follow-up was 18.5 months. There were similar results across prespecified subgroups of patients.

OS served as a secondary endpoint. He also says that more studies are needed to examine why some patients relapse following treatment and others do not. The study observed treatment-related grade 3 or 4 adverse events in 14.4% of the patients in the nivolumab group compared to 45.9% in the ipilimumab group.

"To me, as a clinician, that is really the most practical issue when administering adjuvant therapy", Weber said during a press conference. Nivolumab combined with ipilimumab resulted in longer progression-free survival and a higher objective response rate than ipilimumab alone. "Compared with the high toxicity of ipilimumab, it is much more tolerable for the patients".

Although adjuvant nivolumab after resection may benefit more patients with high-risk disease, several interesting questions arise, Weber said.

"The safety of nivolumab is very promising", Dr Weber added. "The concern about BRAF/MEK is it clearly induces resistance".

John Haanen, PhD, head of the division of medical oncology at Netherlands Cancer Institute, called the CheckMate 238 findings exciting.

Serious treatment-related adverse events (AEs) were reported in 59% of the patients in the nivolumab-plus-ipilimumab group, 21% in the nivolumab group, and 28% in the ipilimumab group.

The benefit shown for nivolumab in metastatic disease and those pilot data provided the impetus for CheckMate 238, a randomised, double-blind, phase III trial comparing adjuvant treatment with nivolumab versus standard of care ipilimumab.

2 Weber J, Mandala M, Del Vecchio M, et al.

Disclosures: Bristol-Myers Squibb funded this study. Please see the abstract for a list of all researchers' relevant financial disclosures.



Like this

loading...
loading...

Latest


12 September 2017
Oklahoma moves up to No. 2 in AP poll behind Alabama
The Buckeyes did extend their streak of 41 polls ranked in the top 10, which dates back to the November 9, 2014. The Fighting Irish of Notre Dame dropped out of the AP college football poll after just one week in the polls.

12 September 2017
Myanmar accused of laying mines, causing Rohingya injuries
The comments were captured on video at the airport in the Indian hill town of Dharamsala, where he has lived in exile for decades. However, Zaw Htay, the spokesman for State Counselor Aung San Suu Kyi , told CNN the government would not be accepting the offer.

12 September 2017
Faulkner delighted with recall to Australian squad
I am excited to back in the group. "It is a good opportunity against a tough opposition in their own country", he said. He is happy to be back after his absence from the squad.

12 September 2017
SC allows 500 temporary licenses for sale of firecrackers in Delhi-NCR
After the ban, licences of the existing firecrackers sellers were suspended and no new licenses were permitted by the government. Reacting to a PIL the top court had banned firecrackers due to heavy pollution caused by the fireworks in the Delhi NCR region.

12 September 2017
Entegris (ENTG) At $26.20 Forms Top; CBRE Group (CBG) Had 4 Bulls
Bank of New York Mellon Corp owned 0.77% of CBRE Group worth $94,816,000 at the end of the most recent quarter. Goldman Sachs downgraded the shares of CBG in report on Wednesday, August 12 to "Conviction-Buy" rating.

12 September 2017
Hurricane makes second Florida landfall
In storm-battered towns up and down Florida's western shores - from Naples and Fort Myers north through Sarasota, Tampa and St. Boats are seen at a marina in Coconut Grove as Hurricane Irma arrives at south Florida , in Miami, Fla., Sept. 10, 2017.

12 September 2017
US Proposes Military Ties With Myanmar Amid Rohingya Crisis
Approximately 130,000 Rohingya Muslims fled Myanmar for Bangladesh on Friday, almost doubling the count from earlier last week. Government spokesman Steffen Seibert said Germany is closely watching the "dramatic situation" in Buddhist-majority Myanmar.

12 September 2017
Gambia Threaten WAFU Boycott Over Controversial Penalty For Ghana
On Sunday, Senegal take on Liberia in their eliminator, at the Cape Coast Stadium followed in the evening by a clash between Burkina Faso and Niger.

12 September 2017
Upcoming iOS leaked, reveals new "iPhone 8" features
For one thing, their background-blurred portrait photos will look more stunning thanks something called Portrait Lighting. The revamped AirPods will feature the charging indicator light being relocated to the front from inside of the case.

12 September 2017
Mourinho plays down Champions League hopes
There's no winter break, like in other countries, although I have to admit that I love the Christmas period in English football. Following the press conference, the midfielder did join up with his colleagues for the open training session.