Health Care

Menopause hormones don't shorten lives, long follow-up says

Menopause hormones don't shorten lives, long follow-up says”

The Women's Health Initiative (WHI) study looked at the effects of estrogen-only and estrogen-progestin combination therapies used in menopausal women to prevent age-related diseases.

She said the findings suggest it's safe for women between the ages of 50 and 60 to try hormone therapy for treatment of menopause symptoms, but not for chronic disease prevention.

A long-term follow-up of more than 27,000 women who were part of the Women's Health Initiative found no link between hormone therapies used in the landmark study and deaths from cardiovascular disease, cancer or other major illnesses.

The percentage of deaths from any cause in women from the hormone therapy group was 27.1 per cent, nearly identical to the 27.6 per cent in the placebo group, suggesting HRT had no effect on mortality rates. The study was halted in 2002, after investigators found the hormone therapy appeared to put women at greater risk of invasive breast cancer, strokes and heart disease.

"It's the ultimate bottom line", said Manson, who was also part of the original research. Most professional health groups, including the North American Menopause Society and the U.S. Preventive Services Task Force, now advise using the supplemental hormones for the shortest period possible, in the lowest dose needed, just to relieve the most severe symptoms of menopause.

Participants were aged 50 to 79 and past menopause, older than typical users, and took larger doses than now recommended.

While the study found no overall increase or decrease in death rates among women between the ages of 50 and 79, the mortality rates were lowest among younger women in the group (aged 50 to 59).

But an 18-year follow-up on these women has shown that there wasn't an increase to risks of death and other disease on those who used the hormones.

Overall, nearly 7,500 women died - about 27 percent each in the hormone and dummy pill groups.

But women who took HRT - where these hormones are prescribed - for two or more years lost an average of 46 ml less of lung volume compared with women who never took HRT. However, among women who initiated hormone therapy in their 60s and 70s, no effect on death rate was observed.

Overall, death rates were similar among women on both types of hormone treatment versus dummy pills.

The pendulum has swung from one extreme to the other when it comes to hormone replacement therapy (HRT) to treat symptoms of menopause.

"Women with existing health problems, for instance asthma, need to be followed more thoroughly through the menopausal transition and be provided with advice on medications that take the changing hormone levels better into account - ideally with a personalised approach", Triebner added. An editorial published with the follow-up study says the results "will hopefully alleviate concerns" about the long-term consequences. "But that is the reason that all-cause mortality is such an important summary measure, since interventions like hormone therapy can have a complex pattern of benefits and risks".



Like this

loading...
loading...

Latest


12 September 2017
Gov Deal expands state of emergency to all GA counties
A fifth shelter was opened in Greensboro on Sunday . "These shelters will provide temporary resources for people and their pets to rest".

12 September 2017
Coffee Production Put At Risk By Two Of Its Main Contributors
This is not the first time that coffee production has been scrutinized by climate alarmists with dire predictions of future doom. Focus on maintaining habitats for wild bees in coffee-growing areas, especially those that are new due to climate change.

12 September 2017
Bell Pottinger's Middle Eastern division looks to separate from British parent
This was over the company's campaign for South Africa's Gupta family and the PRCA said it was likely to "inflame racial discord". The BDO staffer noted that a "number of redundancies " have been made following an assessment of BP's financial position.

12 September 2017
Lakers to retire Kobe Bryant's jersey in December - but which number?
As many of you remember, in his final game with the Lakers, Kobe dropped 60 points in a 101-96 win over the Utah Jazz. Kobe wore #8 from his rookie season in 1996-97 up until 2005-06 before he switched to #24 for the rest of his career.

12 September 2017
Josh Childress Signs Camp Deal With Nuggets
McBride of BSNDenver.com reported Childress signed a one-year non-guaranteed contract but that it's "likely worth more". Former first-round pick Josh Childress will sign with the Denver Nuggets , according to reports.

12 September 2017
PewDiePie claims racial slur 'just slipped out' in apology video
The famous gamer took to YouTube and has apologized for using the racial slur, calling himself an idiot for doing so. PewDiePie , whose real name is Felix Kjellberg , acknowledged the previous controversy that surrounded him before.

12 September 2017
New £10 note: Experts urge to check for special serial numbers
The new £10 note is due to be released on 14 September, following on from the new £5 note release a year ago . For each these cyphers there were 999,000 serial numbers printed, yielding a whopping 59.9 million notes.

12 September 2017
U.S. says it's 'deeply troubled' by Myanmar crisis
Myanmar's army said it has killed almost 400 militants so far, while some Rohingya refugees have complained they were forced to fight by Arsa.

12 September 2017
Clayton Hotel terminates contract with Newstalk after Hook's rape comments
McCann told iMediaEthics by e-mail yesterday, " I can also confirm that we will attempt to cancel the contract from tomorrow. One of the show's sponsors, Clayton Hotels , criticized Hook's remarks, the Irish Independent reported . "I wish I knew".

12 September 2017
Liam Neeson says his days as an action hero are over
Taken would gross $226 million worldwide, launching a franchise and re-branding Neeson as an action star in the Bruce Willis mold. Ballymena actor Liam Neeson has said he won't be making anymore action movies - citing his age as the reason.