Economy

Xtandi/ADT combo extends survival in late-stage prostate cancer study

A phase 3 trial created to assess the addition of enzalutamide to androgen deprivation therapy for men with nonmetastatic castration-resistant prostate cancer met its primary endpoint of improved metastasis-free survival, according to the agents' manufacturers.

"We want to thank the patients, family members and clinicians who participated in the PROSPER trial and helped advance the scientific understanding of the potential role for Xtandi in this prevalent disease", Steven Benner, MD, senior vice president and global therapeutic area head for oncology development at Astellas, said in the release.

An approval to treat non-metastatic CRPC would significantly boost sales of Xtandi, which Pfizer got access to when it bought Medivation for $14 billion past year. And EvercoreISI's Umer Raffat for one is enthusiastic about what this could mean on the revenue side.

"Here's why this trial is so important", he wrote in a note to clients. "It increases the target market size by perhaps more than double".

Xtandi is now approved to treat castration-resistant prostate cancer that has spread to other parts of the body. Raffat estimates that in the US there's a pool of 20,000 patients with this form of prostate cancer in which it hasn't spread to other parts of the body.

Specifically, the Phase 3 trial was evaluating Xtandi plus androgen deprivation therapy (ADT) versus ADT alone in patients with non-metastatic castration-resistant prostate cancer (CRPC). Xtandi met its goal of improving survival without allowing the cancer to spread.

Currently, Xtandi is approved for the treatment of metastatic CRPC based on clinical data from previous studies that showed a statistically significant overall survival benefit versus the placebo in a metastatic CRPC setting.



Like this

Latest


14 September 2017
Samuel Badree helps World XI level series against Pakistan
Thisara Perera and Samuel Badree were the pick of the bowlers as they bagged two wickets each and kept the run-rate in check. Unlike the first match, this time the hosts got off to a good start, courtesy of Fakhar Zaman and Ahmed Shehzad.

14 September 2017
Newmont Mining Corporation (NEM) COO Thomas Ronald Palmer Sells 1250 Shares
Sentry Investment Management LLC increased its stake in shares of Newmont Mining Corporation by 1.0% during the 2nd quarter. The stock of Newmont Mining Corp (NYSE:NEM) earned "Buy" rating by Clarkson Capital on Tuesday, February 16.

14 September 2017
Rio Tinto plc 25.4% Potential Upside Indicated by Macquarie
BidaskClub lowered shares of Rio Tinto PLC from a "strong-buy" rating to a "buy" rating in a research note on Tuesday, July 25th. Todd Asset Management LLC acquired a new position in Rio Tinto PLC during the 1st quarter valued at approximately $44,378,000.

14 September 2017
The camouflage Call of Duty: WW2 PS4 bundle needs to disappear
It will be made available for $299.99 in the U.S. and $379.99 in Canada on November 3 when Call of Duty: WW2 releases . Worldwide pricing is unknown at the moment, but the bundle is confirmed to be coming to Europe.

14 September 2017
Royals Crumble in 9th to Fall to White Sox
The Indians bullpen was near ideal down the stretch, giving up just one hit, culminating in Cody Allen's 27th save of the year. The Chicago White Sox scored 2 runs in the top of the 9th to defeat the Kansas City Royals 5-3 Wednesday afternoon.

14 September 2017
Marsh & McLennan Companies, Inc. (NYSE:MMC) Shares Bought by Edgestream Partners LP
Wells Fargo & Company reissued a "buy" rating on shares of Marsh & McLennan Companies in a research note on Thursday, July 27th. Amf Pensionsforsakring Ab decreased Alphabet Inc stake by 124,565 shares to 225,717 valued at $178.87 million in 2016Q4.

14 September 2017
Dolphins owner Ross pledges $1M to hurricane relief
Players participated in what is considered a normal practice on Wednesday, including meetings and a morning walk-through. Adam Gase and the Dolphins will direct their attention to the recovery effort in South Florida after the Chargers game.

14 September 2017
Rare white giraffes spotted in Kenya
It was evident that the coloration especially on the mother giraffe was not as conspicuous as the baby. A second sighting was reported in March 2016, in Ishaqbini conservancy, Garissa county, Kenya .

14 September 2017
Ryanair Welcomes Labour Jurisdiction Ruling In 'Mons' Court Case
Those rules therefore enable an employee to sue their employer before the courts they regard as being closest to their interests. But a Belgian court in Mons had requested the ECJ's ruling on whether its own judges had jurisdiction.

14 September 2017
Kelly Clarkson 'Gave Up Royalties' to Disassociate Herself From Dr. Luke
Kelly Clarkson is speaking out about Dr Luke again after saying she was blackmailed into working with him previous year . The American Idol victor revealed that since she changed the song from how it was originally written by Dr.



Recommended