Health Care

Cleveland Clinic Researchers Finds Breast Cancer Breakthrough

Cleveland Clinic Researchers Finds Breast Cancer Breakthrough”

A further seven genetic variants were discovered that predispose women specifically to oestrogen-receptor negative breast cancer, which often leads to poorer health outcomes because it does not respond to hormone therapy.

The risk variants identified in the two studies are common: While some are carried by one woman in 100, others are carried by more than half of all women.

Despite this leap in our understanding of the genetic risks of breast cancer, Bader says that the data still can't explain most of breast cancer cases and are not yet widely useful for population screening.

Melanie Rutkowski, of the UVa Cancer and Carter Immunology Centers, was awarded $450,000 by the breast cancer organization Susan G. Komen to examine whether a chronic disruption in the microbiome, the group of bacteria in the gut, can hurt the immune system's ability to battle breast tumors.

United States co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease.

"Given the size of these studies, we expected that we would find a lot of new breast cancer risk variants, but the studies tells us a lot more about which genes are involved, revealing many previously unsuspected genes and genetic mechanisms underlying breast carcinogenesis".

Now, a new study in the journal "Oncotarget" may give a hint as to why some seemingly healthy, normal women get breast cancer.

Professor Chenevix-Trench said the ultimate goal would be to develop a drug that substantially lowered a woman's chances of getting breast cancer, just as people take statins to reduce their risk of heart disease.

Others, known as oestrogen-receptor negative, are not affected by the hormone and are more hard to treat. QIMR Berghofer senior researcher Jonathan Beesley said researchers now knew much more about the genetic mechanisms that might cause breast cancer.

The combined effect of these variants is likely to be "considerable" said the researchers.

"These women may benefit from more intensive screening, starting at a younger age, or can be offered screening by magnetic resonance imaging (MRI), which is more sensitive, allowing early detection and prevention of the disease".

Baroness Delyth Morgan, chief executive of the charity Breast Cancer Now, said: 'This is another exciting step forward in our understanding of the genetic causes of breast cancer.

The new discoveries add to previous research, bringing the total number of known genetic patterns associated with breast cancer to almost 180. These findings will help improve risk prediction.



Like this

loading...
loading...

Latest


24 October 2017
Destiny 2 Festival of the Lost Isn't Happening, No Halloween Event Planned
The company also plans to do major tweaks between seasons during seasons turnovers, as well as introducing new game content. To kick off Season 2, the game's football pitches will be replaced by ice rinks and ice hockey.

24 October 2017
Plane Headed to Vegas Strikes Birds, Diverted to NY
Pilots opted to head toward New York for the emergency landing because of poor weather in Boston, the New York Post reported. A JetBlue plane from Boston to Las Vegas has struck some birds shortly after takeoff and has been diverted to NY .

24 October 2017
Stock Impressing Investors: Intuitive Surgical, Inc. (NASDAQ:ISRG)
Teacher Retirement System Of Texas stated it has 0% of its portfolio in Intuitive Surgical, Inc . (NASDAQ: ISRG ) or 2,644 shares. Public Employees Retirement System of OH owned 0.12% of Intuitive Surgical worth $40,861,000 as of its most recent SEC filing.

24 October 2017
Kinder Morgan Canada Ltd
Private Harbour Investment Management & Counsel LLC raised its position in shares of Kinder Morgan by 0.3% during the 2nd quarter. The fund owned 40,000 shares of the pipeline company's stock after acquiring an additional 10,000 shares during the quarter.

24 October 2017
Trump defends tweets as key to White House victory
Trump claimed that social media allows him to bypass what he typically labels as "fake news" and talk directly to his followers.

24 October 2017
Vikings' Andrew Sendejo Suspended for Hit That Gave Mike Wallace a Concussion
Sendejo was penalised Sunday for a hit on Baltimore Ravens receiver Mike Wallace in the first quarter of Minnesota's 24-16 win. The safety's hit resulted in Wallace sustaining a concussion and missing the rest of Sunday's game .

24 October 2017
Indian shares drift higher; Bharti Airtel climbs 3%
The benchmark BSE index closed up 0.36 percent at 32,506.72, while the broader NSE index ended 0.38 percent higher at 10,184.85. The promoters too, recorded a sharp increase in their wealth following the surge in telecom stocks.

24 October 2017
Boeing signs US$13.8b deal with Singapore Airlines
SIA is due to take delivery of the world's first 787-10 in the first half of 2018, from a 2013 order with Boeing for 30 aircraft. Wichita-based Spirit Aerosystems supplies parts for Boeing airplanes.

24 October 2017
5 injured after school bus overturns in Ellicott City
The crash happened just before 7 a.m.as the bus was headed westbound on Route 100, according to Howard County Police. Maryland Police indicated that the school bus driver, two adults and two 15-year-old students of Mt.

24 October 2017
Suspected kidnapper, Evans quashes attempt to arraign him on fresh charges
He said Evans can not be charged until his application challenging the charges and the court's jurisdiction had been determined. The new charges include conspiracy and the attempted kidnap of Vincent Obianodo, chairman of The Young Shall Grow Motors.