Health Care

Cleveland Clinic Researchers Finds Breast Cancer Breakthrough

Cleveland Clinic Researchers Finds Breast Cancer Breakthrough”

A further seven genetic variants were discovered that predispose women specifically to oestrogen-receptor negative breast cancer, which often leads to poorer health outcomes because it does not respond to hormone therapy.

The risk variants identified in the two studies are common: While some are carried by one woman in 100, others are carried by more than half of all women.

Despite this leap in our understanding of the genetic risks of breast cancer, Bader says that the data still can't explain most of breast cancer cases and are not yet widely useful for population screening.

Melanie Rutkowski, of the UVa Cancer and Carter Immunology Centers, was awarded $450,000 by the breast cancer organization Susan G. Komen to examine whether a chronic disruption in the microbiome, the group of bacteria in the gut, can hurt the immune system's ability to battle breast tumors.

United States co-author Professor Peter Kraft, from the Harvard TH Chan School of Public Health, said the findings revealed a wealth of new information about the genetic mechanisms underlying the disease.

"Given the size of these studies, we expected that we would find a lot of new breast cancer risk variants, but the studies tells us a lot more about which genes are involved, revealing many previously unsuspected genes and genetic mechanisms underlying breast carcinogenesis".

Now, a new study in the journal "Oncotarget" may give a hint as to why some seemingly healthy, normal women get breast cancer.

Professor Chenevix-Trench said the ultimate goal would be to develop a drug that substantially lowered a woman's chances of getting breast cancer, just as people take statins to reduce their risk of heart disease.

Others, known as oestrogen-receptor negative, are not affected by the hormone and are more hard to treat. QIMR Berghofer senior researcher Jonathan Beesley said researchers now knew much more about the genetic mechanisms that might cause breast cancer.

The combined effect of these variants is likely to be "considerable" said the researchers.

"These women may benefit from more intensive screening, starting at a younger age, or can be offered screening by magnetic resonance imaging (MRI), which is more sensitive, allowing early detection and prevention of the disease".

Baroness Delyth Morgan, chief executive of the charity Breast Cancer Now, said: 'This is another exciting step forward in our understanding of the genetic causes of breast cancer.

The new discoveries add to previous research, bringing the total number of known genetic patterns associated with breast cancer to almost 180. These findings will help improve risk prediction.

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