Health Care

Long-term PPI use linked to stomach cancer

Long-term PPI use linked to stomach cancer”

Researchers found that long-term use of proton pump inhibitors to treat acid reflux can significantly increase a person's risk of stomach cancer, the latest negative health effect that has been linked to the drugs.

The risk rises in tandem with the dose and duration of treatment, their BMJ study shows.

To address the potential role of H pylori, the population-based study compared the use of PPIs with H2 blockers in 63,397 adults who had undergone successful eradication of H plyori.

153 participants (0.24%) developed gastric cancer post triple therapy; no participants were diagnosed with H pylori even though all of them had prolonged gastritis. The mean observation period lasted for 7.5 years. And a previous study of long-term use of common PPIs, such as Nexium, Prilosec and Prevacid, suggested they could potentially increase a person's risk for early death.

During that time, 3,271 of the study participants took PPIs for an average of almost three years and 21,729 took H2 blockers.

The results indicated that PPIs were linked with a doubling of the risk (2.44) of developing stomach cancer, whereas H2 blockers were not linked with any such elevated risks.

The average time between triple therapy and the development of stomach cancer was just under five years, the University of Hong Kong study found.

Prolonged usage of PPIs raised the risk by 5 times after a year; over 6 times after two or more years; and over 8 times after three or more years. Furthermore, the longer PPIs were used by patients the higher the risk of developing GC became.

Tucson- The long-term use of some acid reflux medications could increase the risk of stomach cancer.

Overall doctors do not believe this to be damning enough for the removal of PPI, but instead issued the statement that doctors should "exercise caution when prescribing long-term PPIs".

Speaking to The Guardian, Stephen Evans, professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said in response to the study results: "Many observational studies have found adverse effects associated with PPIs".

PPIs are commonly prescribed drugs that reduce the amount of acid produced in the stomach.

Like this



01 November 2017
Singapore leads the world in mobile download speeds
India's LTE Network speeds and footprint are particularly important as it is one of the biggest markets for cellular in the world. Of the 4G service providers in the UK, OpenSignal revealed EE leads the way in download speed (29Mbps) and availability (78%).

01 November 2017
Bin Laden was a big fan of American cinema
Lawmakers on Capitol Hill have been pushing for the full release of the CIA's documents from the raid for months. The journal ran more than 220 pages.

01 November 2017
Amazon Declares The Start Of The Holiday Season
During the holiday season, customers love to discover great deals and must-have holiday gifts for friends and family. The Amazon Black Friday 2017 sale already produced an incredible deal on a Samsung 4K Smart TV.

01 November 2017
Trump says would 'certainly consider' sending NY suspect to Guantanamo
Andrew Cuomo (D) said Wednesday that there was no indication that Saipov was working with others in his attack. Some Republican lawmakers argued the terrorist should be treated as an enemy combatant.

01 November 2017
Michigan Supreme Court Justice Joan Larsen confirmed to U.S. 6th Circuit Court
In early October, the Senate Judiciary Committee voted 11-9, along party lines, to advance Larsen's nomination to the full Senate. She'd been on the Supreme Court of MI since Governor Rick Snyder appointed her to fill an open seat in September of 2015.

01 November 2017
Pakistan envoy in Dhaka summoned for distorting history, apology sought
The 13.45-minute video had initially been posted on the Facebook Page - Pakistan Affairs. It was removed from the high commission's Facebook page after it sparked controversy.

01 November 2017
Notable Stock Analysts Ratings Banco Santander, SA
As of the end of the quarter American Assets Investment Management, LLC had acquired 50,000 shares growing its position 21.0%. TRADEMARK VIOLATION NOTICE: This article was first published by Dispatch Tribunal and is owned by of Dispatch Tribunal.

01 November 2017
Stock In Spotlight: American Capital Agency Corp. (NASDAQ:AGNC)
Aperio Group, LLC says it bought 427,944 shares in the previous quarter increasing its exposure to AGNC Investment Corp .by 38.3%. Crossmark Global Holdings Inc. bought a new stake in shares of AGNC Investment Corp .in the 3rd quarter valued at about $223,000.

01 November 2017
Deadly Navy Collisions in Western Pacific Were 'Avoidable:' Top Navy Officer
In the case of the McCain, the report found, errors compounded following mistakes in operating the ship's steering and propulsion. McCain , which collided with an oil tanker in Southeast Asia on August 21, leaving 10 USA sailors dead and five injured.

01 November 2017
Caesarstone Ltd (CSTE) EPS Estimated At $0.53
The stock has performed -1.91% over the last seven days, -6.14% over the last thirty, and -7.36% over the last three months. The stock of Caesarstone Ltd (NASDAQ:CSTE) earned "Equal-Weight" rating by Barclays Capital on Thursday, February 11.