Health Care

What Causes PCOS? Scientists May Have Finally Found an Answer

What Causes PCOS? Scientists May Have Finally Found an Answer”

The study published in Nature Medicine found that levels of anti-Müllerian hormone (AMH) were 30 per cent higher in pregnant women with condition than those without.

The condition happens due to elevated androgens (male hormones) in females. Millions of women all over the world are affected by the condition, and researchers may have finally found the cause and treatment for it.

A clinical trial using cetrorelix to treat women with PCOS is in the works, with hopes to start before the end of the year.

He told the New Scientist: 'It's by far the most common hormonal condition affecting women of reproductive age but it hasn't received a lot of attention.

The study has been called "radical" and proposes an "attractive strategy" for boosting fertility in women with the condition, which makes it hard to get pregnant. As PCOS can be hereditary, researchers tested to see whether such high levels of AMH in the womb could result in the fetus to have the same condition.

To find out if this excess hormone level was triggering the condition, they injected pregnant mice with anti-Müllerian hormone. What they found was the offspring of the mice injected with high levels of AMH eventually developed excess testosterone and other PCOS symptoms such as late puberty, fewer offspring, and infrequent ovulation.

Robert Normal, from the University of Adelaide, Australia, said: "It's a radical new way of thinking about polycystic ovary syndrome and opens up a whole range of opportunities for further investigation".

PCOS affects between 2.2 and 26.7 percent of women in their childbearing years.

Now, scientists have revealed what they believe might be the cause behind the condition, even admitting that there could be a cure. They surmised that the excess levels of AMH promoted brain cells in the fetus to produce too much testosterone.

Researchers reversed the symptoms of PCOS in the mice by using the IVF drug cetrorelix.

Professor Norman added that the link to the anti-Müllerian hormone could explain why women with PCOS seem to be more likely to get pregnant as they get older. After treatment with this drug, the mice stopped showing symptoms of polycystic ovary syndrome.

Previous research has suggested that a diet with a low glycemic index - the GI diet - could ease symptoms by controlling the amount of insulin produced by the body.



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