Health Care

Fight to end Alzheimer's on The Longest Day

Fight to end Alzheimer's on The Longest Day”

American researchers found that two strains of human herpesvirus were found in the brains of people with Alzheimer's disease at levels up to twice as high as in those without Alzheimer's. "But we were able to perform a more sophisticated computational analysis using multiple levels of genomic information measured directly from affected brain tissue".

Childhood viruses that infect nearly everyone and lie dormant in the body for life might be involved in Alzheimer's disease, researchers reported Thursday. They then found evidence that the viruses influence the behaviour of genes involved in Alzheimer's.

Over the last few years, though, after a series of failed clinical trials into drugs created to attack amyloid plaque build-ups, a growing community of researchers has resurrected this old hypothesis.

The researchers believe that their findings align with other current research in the Alzheimer's field on the role of innate immunity in the disease, particularly recent findings that beta-amyloid protein-the culprit behind the plaques that build up in the Alzheimer's-affected brain-may accumulate as part of a defense against infections.

"The more we learn about the disease process and the more targets we can address", he says, "the greater the probability we are going to slow or prevent the progression of Alzheimer's disease". The researchers initially set out to comprehensively examine DNA, RNA and protein footprints in the brains of deceased Alzheimer's patients with the goal of identifying certain overactive genes in Alzheimer's sufferers that could help direct future drug research.

"We saw a key virus, HHV-6A, regulating the expression of quite a few Alzheimer's risk genes and genes known to regulate the processing of amyloid, a key ingredient in Alzheimer's neuropathology".

"HSV wasn't one of the ones we found in the sequencing of the brain. In those patients, viral proteins were discovered in the spinal fluid of some Lou Gehrig's patients, and patients with positive viral protein tests in their spinal fluid showed benefit when treated with antiviral drugs". Using techniques in bioinformatics, the study integrates high-throughput data into probabilistic networks that are postulated to account for the associations between herpesviruses and the telltale effects of AD. "But what's clear is that they're perturbing networks and participating in networks that directly accelerate the brain towards the Alzheimer's topology".

The research is undoubtedly compelling, but not everyone in the scientific community is convinced it means much.

"The integrated findings of this study suggest that AD biology is impacted by a complex constellation of viral and host factors acting across different timescales and physiological systems", the researchers wrote. In fact, in North America it is estimated that 90 percent of children have at least one of these viruses in their blood early in life.

Doctors don't know what causes Alzheimer's disease or the best way to treat it, but they have new evidence to suggest that a common virus may play a role in who develops the condition.

The research study does not suggest that Alzheimer's disease is contagious. And the two viruses they found to be most strongly associated with Alzheimer's, HHV-6A and HHV-7, were not as abundant in the brains of those with other neurodegenerative disorders.

"When we started analyzing the differences, it just sort of came screaming out at us from the data", Dudley says. "But it would be negligent for us to ignore these results until the next study reports back, which will take several years".

"And now, not only is the viral hypothesis resurrected: it has specific testable pathways and networks and interactions that can be explored and reconciled with the rest of the work emerging in Alzheimer's".

Like this



22 June 2018
Homeland Security drafts plan to end family separation
On Tuesday, Trump argued that sticking by his policies was a winning political strategy as he took a fresh shot at Democrats. The government has said the families could be reunited eventually after the parents were processed in court.

22 June 2018
'He literally lights up a room': Lakers thrilled to draft Michigan's Wagner
He wants his players to make plays, play confident, play fast. "It's something I'm very excited to prove [I can do]". Wagner became the seventh MI basketball player picked in the first round since John Beilein has been the head coach.

22 June 2018
Nigeria slay Iceland 2 0 at World Cup
However, Iceland who are making their first ever appearance at the World Cup, played out a shock 1-1 draw against Argentina. Have a go on this Super Eagles squad selector, and let us know who you'd like to see start for Nigeria vs.

22 June 2018
Nigeria vs. Iceland - Football Match Preview
The Super Eagles can take confidence that all of Nigeria's win at the World Cup has been against European oppositions. These two sides have never met in worldwide competition.

22 June 2018
Drive my auto ! McCartney takes Carpool Karaoke up a gear
Speaking to The Sun , Dave has now revealed that he received a message from James Corden after spoking out about the experience. They then leave the vehicle to visit the barber's shop mentioned in the song - leaving the owner in sheer disbelief.

22 June 2018
Volvo: 25% recycled plastics by 2025
Even the seats make use of recycled bottles, while the under-bonnet sound-absorbing material is made of old Volvo seats. Volvo sold around 570,000 cars previous year made of around five percent of plastics from recycled materials.

22 June 2018
Officer's 'racist' posts key to Sterling Brown suit against Milwaukee police
Brown's attorney, Mark Thomsen , filed the lawsuit in federal court, according to CBS News . "Brown on the basis of his race". Police Chief Alfonso Morales apologized to Brown last month when body-camera video of the arrest was released.

22 June 2018
NHS to get extra £384 million per week after Brexit Government says
Five key questions about the Prime Minister's NHS funding announcement answered. Only 7% said it was "very honest", while 25% said it was "fairly honest".

22 June 2018
Charles Krauthammer Dies at Age 68
He would use those same writing skills as a columnist for the Washington Post and commentator for Fox News . The Pulitzer Prize victor revealed earlier this month that he was in the final stages of cancer.

22 June 2018
UN refugee agency: Record 68.5 million displaced in 2017
The Office of the UN High Commissioner for Refugees released its annual report on Tuesday, one day before World Refugee Day . He cited the recent Italian decision to deny entry to a rescue vessel with 629 refugees and migrants on board.