Chinese scientists create mice with two mothers with gene-editing technology

Chinese scientists create mice with two mothers with gene-editing technology”

It is known that two mice of the same sex born 29 surviving mice without any abnormalities, which lived to adult age and also had children.

Researchers at the Chinese Academy of Sciences published an article today in Cell Stem Cell about their technique, which they say produced healthy children that were able to grow up and reproduce.

The researchers in China have noted that there are still obstacles in achieving their feat with other mammals.

The researchers, based at the Chinese Academy of Sciences, explained that in mammals, because certain maternal or paternal genes are shut off during germline development by a mechanism called genomic imprinting, offspring that don't get genetic material from both a mother and father might be developmentally abnormal or might not be viable.

They also deleted a number of "imprinted" genes from these cells, since such genes normally depend on being paired with a corresponding male gene to work properly.

Typically, a mammalian embryo needs two genomes, each containing a manuscript of genetic instructions from the mother or father.

Experts said that the concept was intriguing for its possible application to human reproduction. Babies with two mothers can actually lead a normal healthy life and can reproduce naturally after they complete adolescence, the research showed. The work, presented October 11 in the journal Cell Stem Cell, looks at what makes it so challenging for animals of the same sex to produce offspring and suggests that some of these barriers can be overcome using stem cells and targeted gene editing.

In creating the "mothers only" mice, the researchers simply injected edited stem cells directly into the egg, which was then implanted into another female mouse.

The current study successfully produced healthy bimaternal pups by making use of haploid embryonic stem cells (ESCs).

"In doing so they were able to artificially overcome some of the usual incompatibility between parents of the same sex, meaning they were able to create relatively healthy offspring with two mothers, and somewhat unhealthy offspring from two fathers that died shortly after birth".

Mammals can produce offspring only through sexual reproduction using an female egg fertilised by male sperm. The embryos were then carried to term in surrogate mothers.

Those pups survived 48 hours after birth, but the researchers are planning to improve the process so that the bi-paternal mice live to adulthood. The researchers took an egg from one mouse and a special type of cell - a haploid embryonic stem cell - from another.

The team concentrated on roughly 100 genes that are activated when they come from both parents, but rely on each other for correct development.

"This research shows us what's possible", Dr. Li says.

"The major impact of this work is the furthering of our fundamental understanding of how imprinting operates in mammals and how it acts as a barrier to uniparental reproduction".

This field of research treads on tricky ethical ground, with previous studies involving genetic editing and novel methods of reproduction prompting fears about the implications if similar processes were eventually applied to humans.

Like this



15 October 2018
PS4 Messaging Bug is Bricking Consoles
The bug, in some instances, has been used during matches to cause the opposing team to crash and be unable to complete a match. Users say that receiving certain messages can "brick" your console, effectively breaking the system.

15 October 2018
Trump against cancelling $110 billion arms deal with Saudi Arabia
Turkey claims that Khashoggi, who wrote for The Washington Post , was killed inside a Saudi diplomatic mission in Turkey. It comes as one of the first signs of the economic pain that Riyadh could suffer over the suspected murder.

15 October 2018
Oil Rebounds Towards $81 but Weaker Demand View Weighs
Both global demand and supply are close to hitting 100 million barrels a day for the first time. The IEA welcomes this boost to supply.

15 October 2018
Elliott wins NASCAR playoff race at Dover - 10/7/2018 4:54:53 PM
The Dawsonville, Ga. native led only 11 of the race's 400 laps but remained within striking distance throughout the entire race. Elliott was passed by victor Kyle Busch with two laps left in the race and fell to 0 for 70 in his career.

14 October 2018
Khawaja steers Australia to battling draw with Pakistan
He also became only the sixth batsmen from Australia to score two fifties and aggregate in excess of 200 in a Test in Asia. Khawaja found the ideal partners in debutant Travis Head (72, 175 balls, 5 fours) and Paine.

14 October 2018
Samsung Galaxy A9 introduced
SamMobile's reporting says the device will sport a 7.3-inch primary OLED display and a 4.6-inch external OLED display . The front is dominated by a 6.3-inch Super AMOLED display that sports full HD+ resolution and an 18.5:9 aspect ratio.

14 October 2018
Doug McDermott sounds off on appreciation of Jimmy Butler’s leadership style
Center Karl-Anthony Towns would not address what happened at that practice or whether a players' meeting was held Thursday. Butler told ESPN following Wednesday's practice that his issues with the Timberwolves have not been fixed.

14 October 2018
Searchers find body in hurricane-stricken town
The hurricane eyewall passed directly overhead, severely damaging almost every building. How many others were not so fortunate was still not clear. "I didn't recognise nothing.

14 October 2018
Google Pixel 3 to launch on November 2nd in France, retailer claims
At first glance, the Pixel 3 XL looks just like the Pixel before it except it has a big notch in the screen. Pixel 3 XL is just the larger variant of Pixel 3 with no difference in camera or performance side.

14 October 2018
‘SNL’ tackles President Trump’s meeting with Kanye West
By the end of the skit, Trump surmises that West is the Black version of him. "He doesn't listen to anyone but himself. He continues: "I feel like when people tell me what to do, I feel like they're touching my brain".