Health Care

In a first, scientists eliminate HIV from an animal's genome

In a first, scientists eliminate HIV from an animal's genome”

Researchers say when the HIV cure is complete, patients would replace taking pills for the rest of their lives with two separate injections.

The use of CRISPR in HIV stirred up much controversy after Chinese scientist He Jiankui claimed to have used the technology to edit human embryos, resulting in the birth of babies with a mutated form of the CCR5 gene that rendered them resistant to HIV. Its effectiveness in protecting humans from the virus is still unknown.

The problematic thing about HIV is it is smart enough to hide from our body's immune system and even more from drugs that we send to attack it.

Testing their methods on a group of infected "humanized mice", or rodents engineered to produce human T cells susceptible to HIV, researchers administered a treatment called LASER ART, or long-acting, slow-effective release ART, to suppress HIV cells from replicating.

Editor's Note: Within hours of Tuesday's announcement, news of the breakthrough study appeared in media outlets around the world, including CNN, CNBC, Time, London's Daily Mail and New Scientist magazine. However, LASER ART takes this a lot further.

HIV integrates its genetic material into the genomes of the host's cells, which now available ART can't target. The nanocrystals are stored within cells for weeks and slowly release the drugs. The drug alone is long-lasting, and infected patients only need to take it at least once a year.

"Our study shows that treatment to suppress HIV replication and gene editing therapy, when given sequentially, can eliminate HIV from cells and organs of infected animals", said Kamel Khalili, director of the center for neurovirology and the Comprehensive NeuroAIDS Center at Temple University's Lewis Katz School of Medicine, who is one of the study's lead authors.

More news: Japan Fisherman Catch First Whales As Commercial Hunts Resume After 30 Years

"We had to be highly efficient and getting a third of these animals cured is fantastic considering what we were up against". But gene editing can't eliminate HIV on its own.

His team used a technique called CRISPR-Cas9 that can snip faulty DNA with a harmless virus. Gendelman and Edagwa are named inventors on patents that cover the LASER ART technology. It is harmless with tremendous benefits - an ideal method to curing HIV. Once infection was established, mice were treated with LASER ART and subsequently with CRISPR-Cas9. At the end of their treatment, about one-third of infected mice had seen HIV eliminated from their DNA, specifically 2 of 7 cured in the first experiment, 3 of 6 in the second, and 6 of 10 in the third.

"You're probably looking at seven to 10 years from where we're at now with this discovery the 'reporting discovery stage, ' " said Dr. Michael Dixon of the UNeMed Corp.

As of now, there is no known cure for HIV or AIDS. If it is stopped, HIV rebounds, renewing replication and fuelling the development of AIDS.

Excision BioTherapeutics, a biotech focused on using CRISPR to treat viral infections, has licensed the gene-editing technology from Temple University, with a plan to advance the platform into human clinical trials.

"Those early cases were patients of mine", Gendelman said. "It shows it's possible that HIV could be cured".



Like this

loading...
loading...

Latest


03 July 2019
Japan resumes whale hunts after 3 decades
After the whale was unloaded from the truck, workers measured it and poured sake on the Minke's body for a purifying ritual. In 1988, Japan stopped commercial hunting of minke and sperm whales in Japanese coastal waters following the moratorium.

03 July 2019
California Gas Tax Increase and New Laws Go Into Effect in July
However, the increase is capped at 1 cent per year under the law that was passed by the Legislature and signed by Gov. New tax increases take effect Monday in IL that will leave some residents digging a little deeper into their wallets.

03 July 2019
Manchester United Have Everything Agreed With Wissam Ben Yedder
Ben Yedder has steadily improved over the past few seasons, culminating in his a prolific 2018/19 campaign. Ben Yedder to Manchester United is seen, by them, as near certain if Lukaku goes.

03 July 2019
'The Walking Dead' comic ends with Issue No. 193
Just last month, we were calling The Walking Dead #192 " the end of an era ", thanks to a stunning issue ( spoilers at that link). I hate that you can feel when you're getting to the end of a book, or a graphic novel. "I love long movies for that very reason".

03 July 2019
ICC CWC'19: Avishka Fernando can be Sri Lanka's 'spark': Mahela Jayawardene
The pop sensations was reunited with her former teacher Roddy Estwick, who is the current West Indies assistant coach . Sri Lanka's ICC World Cup 2019 campaign came to a premature end when England defeated India on June 30 at Edgbaston.

03 July 2019
Peru boss Gareca backs team to reach Copa America final
In the quarterfinals stage the decision went straight to the penalty shootouts if the teams ended level after 90 minutes. Peruvian goalkeeper Pedro Gallese became the hero of the match after saving Suarez's opening penalty.

03 July 2019
China ‘regrets’ Iran’s decision to exceed uranium limit under nuclear deal
No detail has been given on how much enriched uranium Iran has stockpiled except that it is more than 300 kilograms. Iran will increase its level of uranium enrichment starting Sunday, President Hassan Rouhani said.

03 July 2019
Sony swaps PES for Detroit Deluxe Edition in weak July PS+ freebies
Detroit Become Human was first released on the PS4 in May 2018, and is the latest title from David Cage and Quantic Dream. It's unclear why the change was made, but it could be due to licensing issues or the like.

03 July 2019
New Zealand lose top wicket taker Lockie Ferguson for England showdown
A Black Caps spokesperson confirmed to Stuff that Ferguson missed training the day before the England match due to the injury. He resumed his imperious opening partnership with Jonny Bairstow against India and added 160 runs for the opening wicket.

03 July 2019
How can Pakistan reach the World Cup 2019 semi-final?
England vs New Zealand LIVE SCORE, ICC Cricket World Cup 2019 Match Updates: Before we get to today's match, here's some news. England have 10 points, one more than Pakistan , and are back in the top four after the win against India.