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Coronavirus vaccine: Macaque monkey trial offers hope

Coronavirus vaccine: Macaque monkey trial offers hope”

Oxford University has now tested the largest covid-19 vaccine project in Britain, which is included in the world's powerful countries.

At around the same time, British researchers began small-scale human trials of the vaccine. The preliminary findings also indicated that the "ChAdOx1 nCoV-19" vaccine has been effective in preventing damage to the lungs.

The authors wrote: "We observed a significantly reduced viral load in bronchoalveolar lavage fluid and respiratory tract tissue of vaccinated animals challenged with SARS-CoV-2 compared with control animals, and no pneumonia was observed in vaccinated rhesus macaques".

They were then exposed to higher doses of the virus, and the vaccine seemed to protect the lungs from the virus, but not the nose.

Stephen Evans, a professor of pharmacoepidemiology at the London School of Hygiene & Tropical Medicine, said the monkey data were "very definitely" good news.

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A group of American medical experts are preparing to experiment with the tablet form of a vaccine that was manufactured against the Covid-19 virus.

Other vaccines in human trials include those by Moderna Inc, Pfizer Inc and BioNTech SE and China's CanSino Biologics Inc.

Groups likely to be at the head of the line for access are front-line health-care workers and first responders, plus essential workers like grocery, pharmacy, food-supply and mass-transit employees, said Paul Offit, director of the Vaccine Education Center at Children's Hospital of Philadelphia, who serves on a committee with federal and drug-industry officials that is trying to accelerate coronavirus vaccine development. "It's going to be a single dose vaccine".

"One concern with vaccines against CoV species is the potential for antibody dependent enhancement of the disease pathology - this is one reason for the lack of a vaccine against the 2003 SARS CoV strain".

"It was chosen as the most suitable vaccine technology for a SARS-CoV-2 (COVID-19) vaccine as it can generate a strong immune response from one dose and it is not a replicating virus, so it cannot cause an ongoing infection in the vaccinated individual", it added. As on May 13, more than 1000 volunteers have already participated in human clinical trials of this vaccine. The team developing the vaccine says once available it will be a low-cost, very, very extensively available vaccine as soon as possible.



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