Health Care

Antibodies from the 2003 SARS outbreak might help protect against Covid-19

Antibodies from the 2003 SARS outbreak might help protect against Covid-19”

Researchers at the University of Washington School of Medicine say they've discovered that the antibody, called S309, inhibits the 2019 novel coronavirus and other coronavirus strains.

Dr. Herbert Virgin is Executive Vice President of Research and Chief Scientific Officer at the San Francisco-based company Vir Biotechnology.

An immune system run amok may be responsible for some COVID-19 patients faring worse than others, suggests a new worldwide study led by immunology researchers at Israel's Weizmann Institute of Science.

Scientists based in Switzerland and the United States previously isolated the antibodies from the patient in 2003, following the SARS outbreak that killed 774 people.

More news: German man charged over night at the museum in Sydney

Further study revealed that S309 binds to a site on the SARS-CoV-2 spike protein that is conserved across many coronaviruses, which may be why this antibody appears to show activity against multiple coronaviruses. Like COVID-19, SARS was caused by a type of coronavirus, which led researchers to check for therapeutic crossover effects.

Veesler and Davide Corti are senior authors of the Nature study, titled "Cross-Neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV Antibody".

Clinical trials of two drug candidates, which are genetically engineered versions of S309, are expected to begin this summer, in collaboration with GlaxoSmithKline, according to a statement from Vir Biotechnology. "We have seen in animal models of other respiratory infections, such as influenza, that effector function significantly enhances the activity of antibodies that are already potently neutralizing".



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