Vaccine trial by Moderna shows promising early results

Vaccine trial by Moderna shows promising early results”

United States stocks surged Monday on hopes for a coronavirus vaccine that could allow the global economy to emerge from its pandemic-induced coma. The company didn't have detailed data on the rest of the 45 trial participants, but all generated at least some antibodies. He said the results indicate the vaccine has a "high probability to provide protection from COVID-19 disease in humans".

Investors cheered the initial results Monday morning, sending Moderna's stock up almost 30%. The firm's CEO Stephane Bancel said phase one is still ongoing and previewed the next steps of the trial.

A sign marks an entrance to a Moderna, Inc., building, on May 18, 2020, in Cambridge, Mass. Moderna announced May 18, 2020, that an experimental vaccine against the coronavirus showed encouraging results in very early testing, triggering hoped-for immune responses in eight healthy, middle-aged volunteers. He says questions still remain regarding general efficacy, and whether the data can be generalized for other demographics, such as older age groups.

The U.S. National Institute of Allergy and Infectious Diseases led the experiment, also called a trial. The next phase will test doses between 25 and 100 micrograms. One patient at a lower dose level experienced redness at the injection site. The company said that after two doses, all 45 trial participants had developed coronavirus antibodies. The researchers found that at two lower dose levels used in the study, levels of antibodies found after getting a second booster shot of the vaccine either equaled or exceeded the levels of antibodies found in patients who had recovered from the virus. The levels of those so-called neutralising antibodies matched the levels found in patients who had recovered after contracting the virus in the community. What's more, it's promising the antibodies the patients developed were "shown to be effective at limiting the virus's replication in the lab", he added.

Importantly, the vaccine appears to be "generally safe and well-tolerated" with no life-threatening side effects, the company said. The highest dose caused fever, muscle aches, and headaches. "We're doing our best to make it as many millions as possible".

Vaccine trial by Moderna shows promising early results

Moderna has been working closely with the National Institutes of Health since January to find a vaccine and tested the vaccine on mice before moving on to human trials in March.

"The lower the dose, the more vaccine we'll be able to make", Dr Zaks said.

There are now no approved treatments or vaccines for COVID-19. "That being said, this is a new kind of vaccine platform, and some of the safety signals may take time to be recognized".

As the Wall Street Journal reported last week, the debate is raging in the medical community about whether the risks of a human challenge trial are worth it in the case of this virus, and the World Health Organization has already published a document outlining the "ethical acceptability" of such a trial. However, the drug is considered experimental and isn't considered a safe or effective treatment for COVID-19, and needs more clinical study.

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