Health Care

Steroids cut COVID-19 death rates, but not for everyone

Steroids cut COVID-19 death rates, but not for everyone”

Dexamethasone yielded no increase in secondary infections (21.9% vs 29.1% with standard care), and - albeit with a little more need for insulin for glucose control (31.1% vs 28.3%) - fewer cases of other serious adverse events (3.3% vs 6.1%).

"Although the meta-analysis suggests corticosteroids might not be associated with improved mortality in critically ill patients with COVID-19 and shock, this result is prone to bias by both off-protocol corticosteroid use in the usual care group as well as exclusion of patients already receiving corticosteroids at screening", they added.

The study, led in the United Kingdom by Professor Anthony Gordon from Imperial College London with collaborators from the Intensive Care National Audit & Research Centre, found that patients receiving intensive care who were treated with a regular fixed dose of the steroid hydrocortisone for seven days had a better chance of recovery, compared with the patients who were not treated with the steroid.

'It has also come to notice that patients requiring hospitalisation have to wait for long hours at the triaging area of health facilities before they are shifted to the ICU or put on oxygen and ventilators as per requirement.

Researchers are focusing on whether they could use similar corticosteroid drugs in the part of treatment.

Dexamethasone's benefits for COVID-19 critical illness were replicated in a Brazilian randomized trial, while a World Health Organization-sponsored patient-level meta-analysis of ongoing randomized trials concluded that it's a class effect across corticosteroids. That was great news, but those findings created a conundrum for Angus and other researchers who were running their own studies of steroids in COVID-19 patients. In the groups that were given the various steroids, 30% roughly died. "Which is really impressive to see a result like that".

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Simon Stevens, the chief executive of the National Health Service in England, also supported the treatment. He called it the further weapon in the armory in the worldwide fight against COVID-19.

World Health Organization said a "meta-analysis" of seven studies involving over 7,000 participants found steroids like dexamethasone, hydrocortisone and methylprednisolone can reduce the risk of death by up to a third compared to patients who did not receive them.

Studies show that steroids could reduce the risk of death for hospitalized patients on ventilators by about a third.

A new global study published today [02 September] has shown that treating critically ill patients with COVID-19 with the steroid hydrocortisone improves their chances of recovery. We also use these steroids for viral infections. These tests conducted in 88 British hospitals have demonstrated the effectiveness of hydrocortisone, which would save around 1 in 12 patients.

But he added that hydrocortisone is a not a preventive treatment but instead one for severely unwell people in hospital who needed oxygen and were suffering from complications. Researchers from three research groups have now published their findings that they had gathered in the journal JAMA.

The Times' data also shows that the average daily numbers of newly reported coronavirus cases over the past two weeks remained mostly stable in Washington, D.C., and 24 states: Alaska, Arkansas, Colorado, Delaware, Hawaii, Illinois, Indiana, Louisiana, Maine, Maryland, Massachusetts, Michigan, Missouri, New Hampshire, New Jersey, New Mexico, New York, Pennsylvania, Rhode Island, Tennessee, Utah, Vermont, Virginia, and Wisconsin.

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