Health Care

Second Covid-19 trial paused within 24 hours over safety concerns

Second Covid-19 trial paused within 24 hours over safety concerns”

USA pharmaceutical firm Eli Lilly on Tuesday paused a late-stage trial of its experimental lab-produced antibody treatment against Covid-19 over an unspecified safety concern, the company said. Lilly didn't provide information about what caused the panel to recommend the pause.

If Lilly's treatment gets the green light, the study will enroll another 700 patients, including sicker ones who may need supportive care for organ failure.

The clinical trial is created to evaluate Lilly's neutralizing antibody as a treatment for COVID-19 in hospitalized patients in combination with the antiviral drug remdesivir. Scientists work with a bioreactor at a Regeneron facility in NY state, for efforts on an experimental coronavirus antibody drug.

The announcement comes one day after Johnson & Johnson said it was forced to pause a large high-profile trial of its experimental coronavirus vaccine because a volunteer fell ill.

Lilly sought the EUA from United States regulators after publishing data in September showing LY-CoV555 helped cut hospitalization and emergency room visits for COVID-19 patients.

More news: Trade dispute looms as China 'told plants not to use Aussie coal'

News of the pause in the ACTIV-3 trial was first reported by the New York Times, citing emails that government officials sent to researchers at testing sites. As part of Eli Lilly's ACTIV-3 trials, the monoclonal antibody-a combo of two lab-produced proteins that boost the immune system by neutralizing the coronavirus- is used alongside the antiviral remdesivir. A final decision must be made by the monitoring board before any future action is taken.

It was not immediately clear whether the pause would affect other clinical trials that Lilly is running for Covid-19, for example among patients with mild to moderate forms of the disease or as a potential prophylaxis.

The company said it has submitted request for emergency use authorization (EUA) for monotherapy to the U.S. Food and Drug Administration. The BLAZE-1 trial is testing the monotherapy and the combination therapy in patients with early symptoms of Covid-19 who have not been hospitalized.

Lilly serves as the primary sponsor on that trial, collaborating with its co-developer on the LY-CoV555 antibody therapy, Canadian biotech AbCellera Biologics Inc.

Like this



15 October 2020
Gal Gadot defends herself after ‘Imagine video outrage
During a conversation with a magazine, Gadot says that the video was made to lift people's spirits and as a show of unity. Although it was Gadot's idea as she said but only with an idea to do good and pure, but didn't transcend.

15 October 2020
Vaccine can knock down state's 40000 annual flu cases
That doesn't mean you should skip the flu vaccine, however. Some flu symptoms are similar to COVID-19 symptoms. That's a 33% increase from last year's total.

14 October 2020
Why Meghan Markle says she'll never return to social media again
That's so big, you can't even think of what that feels like. "I have a lot of concerns for people that have become obsessed with it".

14 October 2020
The Wanted's Tom Parker Reveals He's Been Diagnosed With A Brain Tumor
He wrote, 'Hey guys, you know that we've both been quiet on social media for a few weeks and it's time to tell you why. One of the biggest contributors to their success was Tom Parker , the lead vocalist of this British Irish Band.

14 October 2020
NASA and eight partner nations sign Artemis Accords
Rovers and other spacecraft can not have their missions jeopardized by others getting too close. Historic sites must be preserved, and any resulting space junk must be properly disposed.

14 October 2020
USA futures muted ahead of next batch of bank earnings
The company also reported third-quarter earnings of $2.20 a share, beating analysts' estimates of $1.98. The world economy contracted by a far smaller 0.1% after the devastating 2008 financial crisis.

14 October 2020
Premier League clubs reject 'Project Big Picture'
Clubs like Gillingham, who are reliant on matchday income, could have to cope without fans inside Priestfield for much of this season.

14 October 2020
Scientists Confirm COVID Reinfection Case As Trump Baselessly Claims To Be Immune
One patient was infected on 17 separate occasions over the study period. "Covid-19 will probably behave the same", she told AFP. He said that evidence from other respiratory viruses suggested widespread reinfections of Covid-19 was by no means impossible.

14 October 2020
Ole Gunnar Solskjaer still has options as Edinson Cavani ruled out
Paul Scholes believes his former teammate Edwin van der Sar would be the ideal director of football for Manchester United . Manchester United suffered a massive 6-1 defeat at the hands of Tottenham in their previous game in the Premier League .

14 October 2020
Samsung starts device promotions in India on Flipkart and Amazon
The iPhone 11 has insane good cameras and insane good performance making it one of the most compelling iPhones ever made. Under usual circumstances, the base variant of the iPhone 11 with 64GB storage will cost you Rs 68,300.