Health Care

Remdesivir useless in covid fight

Remdesivir useless in covid fight”

He said the trial should also hammer the last nail on hydroxychloroquine's use for Covid-19.

World Health Organization discontinued the trial of lopinavir plus ritonavir in July after reviewing its progress in interim results.

"These remdesivir, hydroxychloroquine, lopinavir and interferon regimens appeared to have little or no effect on hospitalized covid-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay", according to the trial results.

"We are concerned that the data from this open-label global trial have not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design", the firm said.

Health experts said the findings could come as a jolt to doctors across India who have been prescribing both remdesivir and hydroxychloroquine to Covid-19 patients under guidelines approved by the Union health ministry and the Indian Council of Medical Research (ICMR).

Less than 1% of USA dentists have tested positive for COVID-19, even though dental procedures generate aerosols that may contain particles of the new coronavirus, according to a survey of 2,200 dentists published on Thursday in the Journal of the American Dental Association.

It is approved for use against COVID-19 in the United Kingdom and Europe, and is among the treatments US President Donald Trump received when he was infected earlier this month.

Think your friends would be interested?

More news: NEET results out: 3 from Guj in top 100

In the trial, 2,750 participants received remdesivir, 954 received hydroxychloroquine, 1,411 received Lopinavir, 651 received Interferon plus Lopinavir, 1,412 Interferon and 4,088 received placebo.

Asked for his opinion, Matthew Spinelli, MD, of University of California, San Francisco, cautioned that Solidarity involved many different settings around the world, with "heterogeneous approaches to the care of hospitalized COVID-19 patients", and thus trials done by the NIH may have more "external validity" to their guidelines.

Differences in patients who participated in the trial at hundreds of clinical sites may undermine the quality of the data, said Prof Peter Galle, who oversees infectiology at Germany's Mainz university hospital.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, acknowledged at the time that remdesivir was not a "knockout" drug.

"The results are unambiguous - there is no impact on mortality", K. Srinath Reddy, president of the New Delhi-based Public Health Foundation of India and member of an worldwide group of researchers who monitored the trial, told The Telegraph. Then, the authors looked at data on almost 740,000 COVID-19 patients and examined the use of drugs that work to protect these processes, asking whether patients who received them fared better - and they did, in some cases.

Remdesivir, was originally developed as a treatment for Ebola. "So far, only corticosteroids have been proven effective against severe and critical COVID-19", WHO's statement added.

Remdesivir received emergency use authorisation from the Food and Drug Administration in the USA on May 1, and has since been given regulatory approval in several other countries.

The Solidarity results are "preliminary", and the European Medicines Agency, the bloc's drug regulator, will examine them to see whether changes are needed in the way the medicines are used, the European Commission said in a statement. "Covid affects millions of people and their families around the world".



Like this

loading...
loading...

Latest


17 October 2020
Trump administration denies California relief for 6 fires
The administration urged California to improve the management of its forests, while Newsom blamed climate change for wildfires. Numerous studies have linked bigger wildfires in America to climate change from the burning of coal, oil and gas.

17 October 2020
Brexit: Angela Merkel urges both sides to keep negotiating
German Chancellor Angela Merkel, Europe's most powerful leader, said after the summit that compromise would be needed for a deal. EU chief Ursula von der Leyen said on Friday European negotiators will be in London next week to pursue post-Brexit talks.

17 October 2020
SpaceX launch delay: When will next batch of Starlink satellites launch?
SpaceX is now in the process of deploying a whole constellation of 12,000 of the internet-beaming Starlink satellites. US users based in rural areas or small towns often only have access to download speeds below 5Mbps.

17 October 2020
Marvel's Avengers Next-Gen Version Pushed to 2021, Kate Bishop Content Delayed
KitGuru Says: It sounds like a lot is being held back to make a bigger push for Marvel's Avengers next year on next-gen consoles. Most players and critics praise the main story, but the game itself is what has caused many to rate it poorly.

17 October 2020
Joaquin Phoenix to play Napoleon Bonaparte in Ridley Scott historical epic 'Kitbag'
He remained the second actor to be awarded the Oscar for a character played by two actors. Joaquin Phoenix as emperor Commodus at'Gladiator' (2000).

17 October 2020
Hunger not just tragedy but also disgrace - pope
Charles Owubah, CEO, Action Against Hunger. "When we choose to eat diverse foods, we encourage a variety of foods to be produced". Today we face serious challenges, which require global efforts.

17 October 2020
Japan to release Fukushima's contaminated water into sea
A government panel said earlier this year that releasing the water into the sea or evaporating it were both "realistic options". Earlier this month, a court found both TEPCO and the Japanese government at fault for failing to prevent the meltdown.

17 October 2020
Donald Trump Retweets Fake Satire Story About Twitter Outage as Fact
NBC moderator Savannah Guthrie responded: "I don't get that". Trump posted the tweet, the matter was still there. At the time of writing, almost two hours after Mr.

16 October 2020
COVID-19: Government will give 'detailed consideration' to recommended Level 5 restrictions
Ronan Glynn noted that they were seeing concerning reports of people going in to work despite experiencing symptoms of Covid-19. The recommendation comes less than two weeks after Nphet controversially recommended the level five restrictions.

16 October 2020
DNA identifies Christine Jessop's killer 36 years later
Guy Paul Morin at the inquiry into his wrongful murder conviction in the Christine Jessop case, December 19, 2005. Christine was kidnapped after leaving her home in the north Toronto area of Queensville on October 3, 1984.