Health Care

Remdesivir useless in covid fight

Remdesivir useless in covid fight”

He said the trial should also hammer the last nail on hydroxychloroquine's use for Covid-19.

World Health Organization discontinued the trial of lopinavir plus ritonavir in July after reviewing its progress in interim results.

"These remdesivir, hydroxychloroquine, lopinavir and interferon regimens appeared to have little or no effect on hospitalized covid-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay", according to the trial results.

"We are concerned that the data from this open-label global trial have not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design", the firm said.

Health experts said the findings could come as a jolt to doctors across India who have been prescribing both remdesivir and hydroxychloroquine to Covid-19 patients under guidelines approved by the Union health ministry and the Indian Council of Medical Research (ICMR).

Less than 1% of USA dentists have tested positive for COVID-19, even though dental procedures generate aerosols that may contain particles of the new coronavirus, according to a survey of 2,200 dentists published on Thursday in the Journal of the American Dental Association.

It is approved for use against COVID-19 in the United Kingdom and Europe, and is among the treatments US President Donald Trump received when he was infected earlier this month.

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In the trial, 2,750 participants received remdesivir, 954 received hydroxychloroquine, 1,411 received Lopinavir, 651 received Interferon plus Lopinavir, 1,412 Interferon and 4,088 received placebo.

Asked for his opinion, Matthew Spinelli, MD, of University of California, San Francisco, cautioned that Solidarity involved many different settings around the world, with "heterogeneous approaches to the care of hospitalized COVID-19 patients", and thus trials done by the NIH may have more "external validity" to their guidelines.

Differences in patients who participated in the trial at hundreds of clinical sites may undermine the quality of the data, said Prof Peter Galle, who oversees infectiology at Germany's Mainz university hospital.

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, acknowledged at the time that remdesivir was not a "knockout" drug.

"The results are unambiguous - there is no impact on mortality", K. Srinath Reddy, president of the New Delhi-based Public Health Foundation of India and member of an worldwide group of researchers who monitored the trial, told The Telegraph. Then, the authors looked at data on almost 740,000 COVID-19 patients and examined the use of drugs that work to protect these processes, asking whether patients who received them fared better - and they did, in some cases.

Remdesivir, was originally developed as a treatment for Ebola. "So far, only corticosteroids have been proven effective against severe and critical COVID-19", WHO's statement added.

Remdesivir received emergency use authorisation from the Food and Drug Administration in the USA on May 1, and has since been given regulatory approval in several other countries.

The Solidarity results are "preliminary", and the European Medicines Agency, the bloc's drug regulator, will examine them to see whether changes are needed in the way the medicines are used, the European Commission said in a statement. "Covid affects millions of people and their families around the world".



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