Health Care

AstraZeneca vaccine shows strong immune response in elderly, appears safe in study

AstraZeneca vaccine shows strong immune response in elderly, appears safe in study”

"As a result, it is crucial that COVID-19 vaccines are tested in this group who are also a priority group for immunization", he said in a news release from the journal The Lancet.

Besides the recipients of the Sinopharm jabs, authorities in Zhejiang said they had made a COVID-19 vaccine developed by the privately owned pharmaceutical company Sinovac Biotec available to high-risk groups in the east China province under the emergency use scheme. One group of the volunteers was given two treatments of the vaccine, called ChAdOx1.

The AstraZeneca/ Oxford vaccine is now in phase 3 trials, which are set to determine its efficacy.

As Axios reported, the next step for the vaccine candidate is to enter Phase III trials, in which the initial clinical group is expanded even further to a larger and more diverse group of participants.

The study's findings, which looked only at data from the phase 2 trial, are important because older adults often have a lessened immune response and are more susceptible to infections, explained the study's lead author, Andrew Pollard. The ongoing study is a single-blind, multicenter, randomized, controlled phase II/III safety and efficacy study.

More news: World Health Organization recommends against use of remdesivir for Covid-19 hospitalised patients

Study recruitment occurred during a national lockdown in the United Kingdom when vulnerable individuals were advised to self-isolate. Those individuals who received two doses had their immune responses assessed on the day of vaccination, and day 1, day 2, and 4 weeks post-vaccination. The incidence of adverse reactions in the 3 micrograms and 6 microgram groups were similar.

LONDON, Nov 20 ― A leading Covid-19 vaccine candidate has shown to safely produce a robust immune response in healthy older adults, its British makers said yesterday as it released its phase 2 trial results.

"One of the most exciting things from our study was that the vaccine stimulated really good antibody production". T-cell response occurred within 14 days of the first dose of vaccination, and antibody response occurred within 28 days of the booster dose of vaccination. And, crucially, the researchers wanted to know if it might work in older people who are most at risk of severe Covid.

"What this could mean is that in the future when we're looking to boost people's responses, we might need to do it more often in older people than we do with younger people, but we're not thinking that we're going to need to boost people a few times a year as we do with the flu vaccine". While CoronaVac was produced with tried-and-true methods, the mRNA technology is new, and there hasn't been an mRNA vaccine approved by the Food and Drug Administration before.

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